Long-term outcomes of intermediate coronary stenosis in patients undergoing hemodialysis after deferred revascularization based on fractional flow reserve

Catheter Cardiovasc Interv. 2022 Nov;100(6):971-978. doi: 10.1002/ccd.30421. Epub 2022 Oct 19.


Objectives: This study aimed to assess the long-term outcomes of patients undergoing hemodialysis (HD) after deferred revascularization based on fractional flow reserve (FFR).

Background: FFR is a practical technique for assessing the functional severity of intermediate coronary stenosis. Prior research has revealed a satisfactory outcome in patients after the deferral of percutaneous coronary intervention for coronary lesions based on FFR measurement. However, little research has been conducted focusing on patients undergoing HD.

Methods: The retrospective study comprised 225 consecutive patients with FFR assessment and deferred revascularization between January 2016 and December 2019. Based on a deferral cutoff FFR value of >0.80, we assessed the differences in all-cause death, major adverse cardiac events (MACEs), and target vessel failure (TVF) between the HD (n = 69) and non-HD groups (n = 156) during a mean ± standard deviation routine follow-up of 32.2 ± 13.4 months.

Results: Although the HD group had significantly higher rates of diabetes mellitus than the non-HD group (53.6% vs. 37.2%, p = 0.021), there were no significant differences in sex, left ventricular ejection fraction, or other risk factors between the groups, nor with respect to stenosis diameter or mean FFR. The HD group had a significantly higher incidence of TVF than the non-HD group (34.8% vs. 14.1%, p < 0.001), as well as a significantly higher risk of all-cause death and MACEs.

Conclusions: The study revealed that deferred revascularization in coronary lesions with an FFR value of >0.80 in patients undergoing HD was associated with poor outcomes. Therefore, it is important to carefully monitor patients with intermediate coronary stenosis undergoing HD.

Keywords: deferred revascularization; fractional flow reserve; hemodialysis patients; intermediate coronary stenosis.

MeSH terms

  • Coronary Angiography
  • Coronary Artery Disease*
  • Coronary Stenosis* / diagnostic imaging
  • Coronary Stenosis* / therapy
  • Fractional Flow Reserve, Myocardial*
  • Humans
  • Myocardial Revascularization / adverse effects
  • Renal Dialysis
  • Retrospective Studies
  • Stroke Volume
  • Treatment Outcome
  • Ventricular Function, Left