Traditional Chinese Medicine JingYinGuBiao Formula Therapy Improves the Negative Conversion Rate of SARS-CoV2 in Patients with Mild COVID-19

Bowu Chen; Peihua Geng; Jiaojiao Shen; Suthat Liangpunsakul; Hua Lyu; Jue Zhang; Yanbing Yang; Lei Zhang; Yuping Xu; Chunling Dong; Yanping Wang; Yan Xue; Wei Zhang; Hua Liu; Man Li; Yueqiu Gao

doi:10.7150/ijbs.76699

Traditional Chinese Medicine JingYinGuBiao Formula Therapy Improves the Negative Conversion Rate of SARS-CoV2 in Patients with Mild COVID-19

Int J Biol Sci. 2022 Sep 1;18(15):5641-5652. doi: 10.7150/ijbs.76699. eCollection 2022.

Authors

Bowu Chen¹, Peihua Geng², Jiaojiao Shen³, Suthat Liangpunsakul⁴, Hua Lyu⁵, Jue Zhang⁶, Yanbing Yang³, Lei Zhang⁷, Yuping Xu³, Chunling Dong³, Yanping Wang³, Yan Xue⁸, Wei Zhang⁹, Hua Liu¹⁰, Man Li⁸, Yueqiu Gao^{1

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Affiliations

¹ Department of Hepatopathy, Shuguang Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
² Medical Department, Shuguang Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
³ Nursing Department, Shuguang Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
⁴ Division of Gastroenterology and Hepatology, Department of Medicine, Indiana University, USA.
⁵ National Monitoring Center for Medical Services Quality of TCM Hospital, Shanghai, China.
⁶ Clinical Laboratory, Shuguang Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
⁷ General Affairs Department, Shuguang Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
⁸ Laboratory of Cellular Immunity, Institute of Clinical Immunology, Shuguang Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
⁹ Respiratory Department, Shuguang Hospital, Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
¹⁰ Division of Service supervision of Traditional Chinese Medicine, Shanghai Municipal Health Commission, Shanghai, China.
¹¹ Institute of Infectious diseases of integrated traditional Chinese and Western medicine, Shanghai, China.

Abstract

Background: Traditional Chinese Medicine (TCM) JingYinGuBiao formula (JYGB) was recommended by the Expert consensus on Traditional Chinese Medicine diagnosis and treatment of COVID-19 infection in Shanghai. We evaluated the safety and efficacy of JYGB in treating mild COVID-19 patients. Methods: A prospective, double-blind, randomized, controlled trial was conducted (ClinicalTrial.gov registration number: ChiCTR2200058695). A total of 885 patients were randomized into the treatment group (administration of JYGB,n=508) or the control group (administration of TCM placebo, n=377) with 7-day treatment. The primary outcomes were the negative conversion rate and negative conversion time of SARS-CoV2 RNA. Secondary outcomes included the hospitalized days and symptom improvement. Results: A total of 490 and 368 patients in the treatment and control groups completed the study. The cumulative negative conversion rates at 2 days, 3 days, 4 days, and 6 days post randomization in the treatment group were all markedly higher than those in the control group (13.88% vs. 9.24%, P=0.04; 32.24% vs. 16.58%, P<0.001; 51.43% vs. 36.14%, P <0.001; 77.76% vs. 69.84%, P=0.008). Compared with the control group, after JYGB treatment, the median negative conversion time (4.0 [3.0-6.0] vs. 5.0 [4.0-7.0] days, P<0.001) and hospitalized days (6.0 [4.0-8.0] vs. 7.0 [5.0-9.0] days, P<0.001) were reduced. While the symptoms were improved, there were no significant differences in symptom disappearance rates between both groups. In addition, further sub-group analysis showed that for patients with interval time ≤4 days or patients≤ 60 years, the clinical effects of JYGB were more remarkable with an increase in cumulative negative conversion rates, a decrease in negative conversion time and hospitalized days. JYGB was well tolerated without any severe side effects. Conclusion: JYGB, a TCM prescription, improves the negative conversion rate of SARS-CoV2 in mild COVID-19 patients.

Keywords: COVID-19; JingYinGuBiao formula; negative conversion rate; negative conversion time; traditional Chinese medicine.

Publication types

Randomized Controlled Trial
Research Support, Non-U.S. Gov't

MeSH terms

COVID-19 Drug Treatment*
China
Humans
Medicine, Chinese Traditional
Prospective Studies
RNA, Viral
SARS-CoV-2
Treatment Outcome

Substances

RNA, Viral