Clinical Manifestations of Varicella: Disease Is Largely Forgotten, but It's Not Gone

J Infect Dis. 2022 Oct 21;226(Suppl 4):S380-S384. doi: 10.1093/infdis/jiac390.


After 25 years of varicella vaccination in the United States, classic varicella and its complications have become an uncommon occurrence. The clinical manifestation of varicella among vaccinated persons is usually modified, with fewer skin lesions, mostly maculopapular, and milder presentation. However, the potential for severe manifestations from varicella still exists among both vaccinated and unvaccinated persons, and thus healthcare providers should keep varicella in the differential diagnosis of a maculopapular or vesicular rash. The prompt recognition and diagnosis of varicella is important because when confirmed, clinical and public health measures need to be taken swiftly.

Keywords: breakthrough; chickenpox; maculopapular rash; varicella vaccine; varicella-zoster virus.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Chickenpox Vaccine
  • Chickenpox* / diagnosis
  • Chickenpox* / epidemiology
  • Chickenpox* / prevention & control
  • Herpesvirus 3, Human
  • Humans
  • Memory Disorders
  • Public Health
  • United States / epidemiology
  • Vaccination


  • Chickenpox Vaccine