An Update on Diagnostic Laboratory Biomarkers for Multiple Sclerosis

doi:10.1007/s11910-022-01227-1

Review

. 2022 Oct;22(10):675-688.

doi: 10.1007/s11910-022-01227-1. Epub 2022 Oct 21.

An Update on Diagnostic Laboratory Biomarkers for Multiple Sclerosis

Marwa Kaisey¹, Ghazal Lashgari², Justyna Fert-Bober², Daniel Ontaneda³, Andrew J Solomon⁴, Nancy L Sicotte²

Affiliations

¹ Cedars-Sinai Medical Center Department of Neurology, 127 S. San Vicente Blvd, A6600, Los Angeles, CA, 90048, USA. Marwa.Kaisey@csmc.edu.
² Cedars-Sinai Medical Center Department of Neurology, 127 S. San Vicente Blvd, A6600, Los Angeles, CA, 90048, USA.
³ Mellen Center for Multiple Sclerosis, Neurological Institute, Cleveland Clinic, 9500 Euclid Ave. U10 Mellen Center, Cleveland, OH, 44106, USA.
⁴ Department of Neurological Sciences, Larner College of Medicine at the University of Vermont University Health Center, Arnold 2, 1 South Prospect Street, Burlington, VT, 05401, USA.

PMID: 36269540
DOI: 10.1007/s11910-022-01227-1

Review

An Update on Diagnostic Laboratory Biomarkers for Multiple Sclerosis

Marwa Kaisey et al. Curr Neurol Neurosci Rep. 2022 Oct.

. 2022 Oct;22(10):675-688.

doi: 10.1007/s11910-022-01227-1. Epub 2022 Oct 21.

Authors

Marwa Kaisey¹, Ghazal Lashgari², Justyna Fert-Bober², Daniel Ontaneda³, Andrew J Solomon⁴, Nancy L Sicotte²

Affiliations

¹ Cedars-Sinai Medical Center Department of Neurology, 127 S. San Vicente Blvd, A6600, Los Angeles, CA, 90048, USA. Marwa.Kaisey@csmc.edu.
² Cedars-Sinai Medical Center Department of Neurology, 127 S. San Vicente Blvd, A6600, Los Angeles, CA, 90048, USA.
³ Mellen Center for Multiple Sclerosis, Neurological Institute, Cleveland Clinic, 9500 Euclid Ave. U10 Mellen Center, Cleveland, OH, 44106, USA.
⁴ Department of Neurological Sciences, Larner College of Medicine at the University of Vermont University Health Center, Arnold 2, 1 South Prospect Street, Burlington, VT, 05401, USA.

PMID: 36269540
DOI: 10.1007/s11910-022-01227-1

Abstract

Purpose: For many patients, the multiple sclerosis (MS) diagnostic process can be lengthy, costly, and fraught with error. Recent research aims to address the unmet need for an accurate and simple diagnostic process through discovery of novel diagnostic biomarkers. This review summarizes recent studies on MS diagnostic fluid biomarkers, with a focus on blood biomarkers, and includes discussion of technical limitations and practical applicability.

Recent findings: This line of research is in its early days. Accurate and easily obtainable biomarkers for MS have not yet been identified and validated, but several approaches to uncover them are underway. Continue efforts to define laboratory diagnostic biomarkers are likely to play an increasingly important role in defining MS at the earliest stages, leading to better long-term clinical outcomes.

Keywords: Biomarkers; Diagnosis; Multiple Sclerosis.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

1. Freedman MS, et al. Moving toward earlier treatment of multiple sclerosis: Findings from a decade of clinical trials and implications for clinical practice. Mult Scler Relat Disord. 2014;3(2):147–55. - PubMed
1. Solomon AJ, Corboy JR. The tension between early diagnosis and misdiagnosis of multiple sclerosis. Nat Rev Neurol. 2017;13(9):567–72. - PubMed
1. Zalc B. One hundred and fifty years ago Charcot reported multiple sclerosis as a new neurological disease. Brain. 2018;141(12):3482–8. - PubMed - PMC
1. Kaisey M, et al. Incidence of multiple sclerosis misdiagnosis in referrals to two academic centers. Mult Scler Relat Disord. 2019;30:51–6. - PubMed
1. Kelly SB, et al. Multiple sclerosis, from referral to confirmed diagnosis: an audit of clinical practice. Mult Scler J. 2011;17(8):1017–21.

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[1] Freedman MS, et al. Moving toward earlier treatment of multiple sclerosis: Findings from a decade of clinical trials and implications for clinical practice. Mult Scler Relat Disord. 2014;3(2):147–55. - PubMed

[2] Freedman MS, et al. Moving toward earlier treatment of multiple sclerosis: Findings from a decade of clinical trials and implications for clinical practice. Mult Scler Relat Disord. 2014;3(2):147–55. - PubMed

[3] Solomon AJ, Corboy JR. The tension between early diagnosis and misdiagnosis of multiple sclerosis. Nat Rev Neurol. 2017;13(9):567–72. - PubMed

[4] Solomon AJ, Corboy JR. The tension between early diagnosis and misdiagnosis of multiple sclerosis. Nat Rev Neurol. 2017;13(9):567–72. - PubMed

[5] Zalc B. One hundred and fifty years ago Charcot reported multiple sclerosis as a new neurological disease. Brain. 2018;141(12):3482–8. - PubMed - PMC

[6] Zalc B. One hundred and fifty years ago Charcot reported multiple sclerosis as a new neurological disease. Brain. 2018;141(12):3482–8. - PubMed - PMC

[7] Kaisey M, et al. Incidence of multiple sclerosis misdiagnosis in referrals to two academic centers. Mult Scler Relat Disord. 2019;30:51–6. - PubMed

[8] Kaisey M, et al. Incidence of multiple sclerosis misdiagnosis in referrals to two academic centers. Mult Scler Relat Disord. 2019;30:51–6. - PubMed

[9] Kelly SB, et al. Multiple sclerosis, from referral to confirmed diagnosis: an audit of clinical practice. Mult Scler J. 2011;17(8):1017–21.

[10] Kelly SB, et al. Multiple sclerosis, from referral to confirmed diagnosis: an audit of clinical practice. Mult Scler J. 2011;17(8):1017–21.

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An Update on Diagnostic Laboratory Biomarkers for Multiple Sclerosis

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An Update on Diagnostic Laboratory Biomarkers for Multiple Sclerosis

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