Intracranial hemangioma-associated cranial nerve VII palsy treated with propranolol in an infant with possible PHACE syndrome

Pediatr Dermatol. 2022 Nov;39(6):950-951. doi: 10.1111/pde.15078. Epub 2022 Oct 22.


A 2-week-old infant with a large vascular birthmark involving her right face presented with right-sided facial paralysis. MRI of the brain revealed multiple intracranial hemangiomas, and the hemangioma within the right temporal bone impinged on the facial nerve, which resulted in paralysis. Cranial nerve palsies are a rare neurological manifestation of PHACE syndrome. We report successful treatment of the facial nerve palsy with oral propranolol.

Keywords: bell palsy; facial nerve; hemangioma; propranolol; stroke.

Publication types

  • Case Reports

MeSH terms

  • Brain Neoplasms*
  • Facial Nerve
  • Facial Paralysis* / complications
  • Female
  • Hemangioma* / complications
  • Hemangioma* / drug therapy
  • Humans
  • Infant
  • Propranolol / therapeutic use
  • Syndrome


  • Propranolol

Supplementary concepts

  • PHACE association