Insulin resistance and accelerated cognitive aging

Psychoneuroendocrinology. 2023 Jan:147:105944. doi: 10.1016/j.psyneuen.2022.105944. Epub 2022 Sep 27.


Insulin resistance may be an early sign of metabolic dysfunction with the potential to lead to neuropsychiatric sequelae in the long term. In order to identify whether insulin resistance in otherwise healthy young and middle-aged adults is associated with preclinical signs of neuropsychiatric impairment, we recruited 126 overweight but nondiabetic, nondepressed individuals who completed an insulin suppression test for direct measurement of insulin resistance as well as a battery of cognitive and neuropsychiatric measures. Insulin resistance was associated with weaker performance on a fine motor task (Purdue Pegboard) as well as increases in subclinical symptoms of depression. We submit that insulin resistance in early to mid-adulthood may be an important predictor of long-term risk for metabolic, psychiatric, and neurobehavioral dysfunction.

Keywords: Allostatic load; Cognition; Cognitive decline; Diabetes; Insulin resistance; Obesity.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aging
  • Cognitive Aging*
  • Cognitive Dysfunction*
  • Humans
  • Insulin
  • Insulin Resistance*
  • Middle Aged
  • Overweight


  • Insulin