"How we treat" clinical dilemmas in antiphospholipid syndrome: A case-based approach

Eur J Intern Med. 2023 Jan:107:1-6. doi: 10.1016/j.ejim.2022.10.010. Epub 2022 Oct 20.

Abstract

Antiphospholipid syndrome (APS) is an autoimmune condition characterized by thrombosis (arterial, venous, and microvascular) and/or pregnancy morbidity occurring in subjects persistently positive for antiphospholipid antibodies (aPL). While the APS classification criteria are being currently updated to improve homogeneity in clinical research, patients who seek medical treatment often have a variety of laboratory and clinical characteristics that may not completely fulfill the classification criteria for overt APS. Those cases might represent a challenge in terms of treatment and overall management. We aim to present a collection of challenging scenarios of patients who tested positive for aPL and to discuss available literature to guide the therapeutic strategies.

Keywords: Antiphospholipid antibodies; Antiphospholipid syndrome; Complex cases; Treatment.

Publication types

  • Review

MeSH terms

  • Antibodies, Antiphospholipid
  • Antiphospholipid Syndrome* / diagnosis
  • Antiphospholipid Syndrome* / therapy
  • Female
  • Humans
  • Pregnancy
  • Thrombosis*

Substances

  • Antibodies, Antiphospholipid