Iridoids and sesquiterpenoids from Valeriana officinalis and their bioactivities

Dao-Qun Shi; Jia-Jin Liu; Yu-Mei Feng; Yan Zhou; Cai-Cen Liao; Dan Liu; Rong-Tao Li; Hong-Mei Li

doi:10.1016/j.phytochem.2022.113478

Iridoids and sesquiterpenoids from Valeriana officinalis and their bioactivities

Phytochemistry. 2023 Jan:205:113478. doi: 10.1016/j.phytochem.2022.113478. Epub 2022 Oct 20.

Authors

Dao-Qun Shi¹, Jia-Jin Liu², Yu-Mei Feng², Yan Zhou², Cai-Cen Liao², Dan Liu², Rong-Tao Li³, Hong-Mei Li⁴

Affiliations

¹ Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China. Electronic address: 1730658315@qq.com.
² Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China.
³ Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China. Electronic address: rongtaolikm@163.com.
⁴ Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, Yunnan, PR China. Electronic address: lihongmei0823@163.com.

PMID: 36273591
DOI: 10.1016/j.phytochem.2022.113478

Abstract

Twenty-six iridoids, including six undescribed ones (iridoidvols A-F) and an undescribed natural one, along with ten known sesquiterpenoids were isolated from the roots and rhizomes of Valeriana officinalis. Structurally, iridoidvol A is the first example of iridoid with sesquiterpenoid acid ester. In addition, all of the isolates were evaluated for anti-inflammatory and anti-influenza virus activities. Among them, isovaltrate isovaleroyloxyhydrin exhibited a significant inhibitory effect on NO production with an IC₅₀ value of 19.00 μM.

Keywords: Anti-inflammatory; Anti-influenza virus; Caprifoliaceae; Iridoids; Sesquiterpenoids; Valeriana officinalis.

MeSH terms

Iridoids / pharmacology
Valerian*

Substances

Iridoids