pH and its applications in targeted drug delivery

Sadikalmahdi Abdella; Fatima Abid; Souha H Youssef; Sangseo Kim; Franklin Afinjuomo; Constance Malinga; Yunmei Song; Sanjay Garg

doi:10.1016/j.drudis.2022.103414

pH and its applications in targeted drug delivery

Drug Discov Today. 2023 Jan;28(1):103414. doi: 10.1016/j.drudis.2022.103414. Epub 2022 Oct 20.

Authors

Sadikalmahdi Abdella¹, Fatima Abid², Souha H Youssef², Sangseo Kim², Franklin Afinjuomo², Constance Malinga², Yunmei Song², Sanjay Garg³

Affiliations

¹ Centre for Pharmaceutical Innovation (CPI), University of South Australia, Adelaide, SA 5000, Australia; Department of Pharmacology and Clinical Pharmacy, College of Health Sciences, Addis Ababa University, Zambia St, Addis Ababa, Ethiopia.
² Centre for Pharmaceutical Innovation (CPI), University of South Australia, Adelaide, SA 5000, Australia.
³ Centre for Pharmaceutical Innovation (CPI), University of South Australia, Adelaide, SA 5000, Australia. Electronic address: sanjay.garg@unisa.edu.au.

PMID: 36273779
DOI: 10.1016/j.drudis.2022.103414

Abstract

Physiologic pH is vital for the normal functioning of tissues and varies in different parts of the body. The varying pH of the body has been exploited to design pH-sensitive smart oral, transdermal and vaginal drug delivery systems (DDS). The DDS demonstrated promising results in hard-to-treat diseases such as cancer and Helicobacter pylori infection. In some cases, a change in pH of tissues or body fluids has also been employed as a useful diagnostic biomarker. This paper aims to comprehensively review the development and applications of pH-sensitive DDS as well as recent advances in the field.

Keywords: acidic; alkaline; diseases; formulations; pH-sensitive; targeted drug delivery.

Publication types

Review

MeSH terms

Drug Carriers / therapeutic use
Drug Delivery Systems / methods
Helicobacter Infections* / drug therapy
Helicobacter pylori*
Humans
Hydrogen-Ion Concentration
Neoplasms* / drug therapy

Substances

Drug Carriers