Trimester two gestational exposure to bisphenol A and adherence to mediterranean diet are associated with adolescent offspring oxidative stress and metabolic syndrome risk in a sex-specific manner

Astrid N Zamora; Elizabeth Marchlewicz; Martha M Téllez-Rojo; Charles F Burant; Alejandra Cantoral; Peter X K Song; Adriana Mercado; Dana C Dolinoy; Karen E Peterson

doi:10.3389/fnut.2022.961082

Trimester two gestational exposure to bisphenol A and adherence to mediterranean diet are associated with adolescent offspring oxidative stress and metabolic syndrome risk in a sex-specific manner

Front Nutr. 2022 Oct 5:9:961082. doi: 10.3389/fnut.2022.961082. eCollection 2022.

Authors

Affiliations

¹ Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI, United States.
² Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, United States.
³ Center for Research on Nutrition and Health, National Institute of Public Health, Cuernavaca, Mexico.
⁴ Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, United States.
⁵ Health Department, Iberoamerican University, Mexico City, Mexico.
⁶ Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, United States.

Abstract

Background: Exposure to prenatal bisphenol A (BPA) and Mediterranean Diet Score (MDS) has been linked to metabolic risk in child offspring. It remains unclear if independent and interactive effects persist in adolescence.

Methods: We examined prenatal BPA and MDS on adolescent offspring metabolic syndrome risk score (MRS) and 8-isoprostane (8-iso), a biomarker of oxidative stress. Data from maternal-adolescent dyads from a Mexico City cohort were utilized, including trimester-specific prenatal BPA from spot urine and MDS from food frequency questionnaires. Offspring socio-demographic data and biomarkers to estimate MRS and 8-iso were obtained during peri-adolescence.

Results: Adjusted linear regression models examined associations between trimester-specific BPA, MDS, and BPA^*MDS on outcomes. Sex-stratified analyses revealed a significant association between MDS with increased 8-iso (β = 0.064, p < 0.05), and a marginal association between trimester two BPA with increased 8-iso (β = 0.237), while MDS modified the marginal association between BPA and 8-iso in females (β = 0.046). A negative, marginal association was observed between trimester two BPA and MRS (β = - 0.728), while BPA ^* MDS was marginally, positively associated with MRS (β = 0.152) in males.

Conclusions: Study findings indicate that trimester two prenatal BPA and maternal adherence to a Mediterranean diet may have sexually dimorphic effects on adolescent offspring oxidative stress and metabolic syndrome risk.

Keywords: adolescent health; bisphenol A; early-life exposures; mediterranean diet score; metabolic syndrome risk; oxidative stress.

Abstract

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