Alginate-modified mesoporous bioactive glass and its drug delivery, bioactivity, and osteogenic properties

Haiyan Yao; Jun Luo; Yunyun Deng; Zhihua Li; Junchao Wei

doi:10.3389/fbioe.2022.994925

Alginate-modified mesoporous bioactive glass and its drug delivery, bioactivity, and osteogenic properties

Front Bioeng Biotechnol. 2022 Oct 5:10:994925. doi: 10.3389/fbioe.2022.994925. eCollection 2022.

Authors

Haiyan Yao^{1

2

3}, Jun Luo^{1

3

4}, Yunyun Deng^{1

3}, Zhihua Li^{1

3

4}, Junchao Wei^{1

2

3

4}

Affiliations

¹ School of Stomatology, Nanchang University, Nanchang, China.
² College of Chemistry, Nanchang University, Nanchang, China.
³ Jiangxi Province Key Laboratory of Oral Biomedicine, Nanchang, China.
⁴ Jiangxi Province Clinical Research Center for Oral Disease, Nanchang, China.

Abstract

Mesoporous bioactive glass (MBG) is widely used in bone tissue repairing and drug loading. However, burst release of drug and poor compatibility with other materials limited its application. It is an effective way to modify MBG with a polymer brush to improve the properties. Herein, an alginate-modified MBG was prepared, and then, the effects of ALG on the properties of MBG were investigated. The results demonstrate that ALG could improve the drug loading efficiency, prolong drug release times, and make orderly deposition of apatite on the surface of MBG. Furthermore, MBG@ALG significantly promoted the osteogenic differentiation of MC3T3-E1 cells, demonstrating that surface modification of MBG by ALG can improve its properties, which will further broaden the application of MBG in tissue engineering.

Keywords: alginate; bone regeneration; drug loading; mesoporous bioactive glass; surface modification.