Second-degree burn induced by high-concentration topical capsaicin with mobility sequelae: A case report

Pain Pract. 2023 Feb;23(2):216-219. doi: 10.1111/papr.13175. Epub 2022 Nov 16.


High-concentration topical capsaicin is used as a second-line treatment for neuropathic pain. Transient, mild burning sensation and erythema are expected adverse drug reactions. Here, we report the first case of second degree burn after the application of a high-concentration topical capsaicin patch with secondary mobility sequelae. Nine months after the application, neuropathic pain still remained and the patient described mobility difficulties in daily activities, preventing her from returning to work. This report aims to raise the question of the benefit/risk ratio of high concentration topical capsaicin.

Keywords: adverse drug reaction; capsaicin; neuropathic pain; pharmacovigilance; sequelae.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Burns* / drug therapy
  • Burns* / etiology
  • Capsaicin / adverse effects
  • Female
  • Humans
  • Neuralgia* / drug therapy
  • Neuralgia* / etiology


  • Capsaicin