Role of adjunct anticoagulant or thrombolytic therapy in cardiac arrest without ST-segment-elevation or percutaneous coronary intervention: A systematic review and meta-analysis

Am J Emerg Med. 2023 Jan:63:1-4. doi: 10.1016/j.ajem.2022.10.030. Epub 2022 Oct 19.


This study sought to compare the impact of additional anticoagulation or thrombolytic therapy in patients with cardiac arrest without ST-segment-elevation on electrocardiography and not receiving percutaneous coronary intervention. Three studies (two randomized controlled studies and one observational study) were included, which demonstrated that use of anticoagulation or thrombolytic therapy was associated with higher risk of bleeding, without improvements in time to return of spontaneous circulation or in-hospital mortality.

Keywords: Anticoagulation; Bleeding; Cardiac arrest; Medical management; Thrombosis.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Anticoagulants / therapeutic use
  • Heart Arrest* / therapy
  • Humans
  • Observational Studies as Topic
  • Percutaneous Coronary Intervention*
  • Thrombolytic Therapy


  • Anticoagulants