Low socioeconomic status was associated with a higher mortality risk in multiple sclerosis

Floriane Calocer; Huah Shin Ng; Feng Zhu; Yinshan Zhao; Olivier Dejardin; Emmanuelle Leray; Gilles Defer; Charity Evans; John D Fisk; Ruth Ann Marrie; Helen Tremlett

doi:10.1177/13524585221129963

Low socioeconomic status was associated with a higher mortality risk in multiple sclerosis

Mult Scler. 2023 Mar;29(3):466-470. doi: 10.1177/13524585221129963. Epub 2022 Oct 25.

Authors

Affiliations

¹ Department of Medicine, Division of Neurology and the Djavad Mowafaghian Centre for Brain Health, University of British Columbia, UBC Hospital, Vancouver, BC, Canada.
² UNICAEN, CHU de Caen, INSERM U1086 ANTICIPE, Pôle de Recherche, Normandie University, Caen, France.
³ EHESP Rennes, Sorbonne Paris Cité, Rennes, France; CIC-P 1414, CHU Rennes, West Neuroscience Network of Excellence (WENNE), Rennes, France.
⁴ UNICAEN, CHU de Caen Normandie Department of Neurology, MS Expert Center, Normandie University, Caen, France; Réseau Bas-Normand Pour la Prise en Charge de la SEP, Caen, France.
⁵ College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada.
⁶ Nova Scotia Health Authority and the Departments of Psychiatry, Psychology and Neuroscience, and Medicine, Dalhousie University, Halifax, NS, Canada.
⁷ Departments of Internal Medicine and Community Health Sciences, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.

PMID: 36281835
DOI: 10.1177/13524585221129963

Abstract

Background: The relationship between socioeconomic status (SES) and mortality among persons with multiple sclerosis (PwMS) is poorly understood.

Objective: To investigate the association between SES and mortality risk in PwMS.

Methods: From health-administrative data, we identified 12,126 incident MS cases with a first demyelinating event (MS 'onset') occurring between 1994 and 2017. Cox proportional hazard model assessed the association between socioeconomic status quintiles (SES-Qs) at MS onset and all-cause mortality.

Results: Lower SES-Qs were associated with higher mortality risk; adjusted hazard ratios: SES-Q1 (most deprived) =1.61 (95% confidence interval (CI) = 1.36-1.91); SES-Q2 = 1.26 (95% CI = 1.05-1.50); SES-Q3 = 1.22 (95% CI = 1.02-1.46); SES-Q4 = 1.13 (95% CI = 0.94-1.35) versus SES-Q5 (least deprived).

Conclusion: A lower SES was associated with higher mortality risk in PwMS.

Keywords: Multiple sclerosis; mortality risk; population-based study; socioeconomic disparities; socioeconomic status.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Low Socioeconomic Status*
Multiple Sclerosis*
Proportional Hazards Models
Social Class

Abstract

Publication types

MeSH terms

Grants and funding