Significant progress has been made in lung cancer screening, surgery, chemoradiation, targeted therapy, and immunotherapy recently. Surgical resection is the most important treatment for localized non-small cell lung cancer (NSCLC) so far, but there are still many patients who develop local recurrence or distant metastases within 5 years of surgery. Currently, the risk factors of recurrence in patients with NSCLC are mainly based on clinical and pathological features, which hardly identify patients at high risk of recurrence accurately. With the development of new detection technologies, a number of molecular markers that may have a predictive risk of recurrence in NSCLC have been discovered over the years. In order to summarize the molecular markers related to postoperative recurrence in NSCLC patients, we have formulated a consensus on the prediction of postoperative recurrence of NSCLC based on molecular markers. This consensus mainly focuses on the early stage NSCLC patients, discusses and summarizes the risk factors of disease recurrence from the molecular level. It is hoped that more and more valuable information can be provided for the management of patients, so as to provide more guidance for the perioperative management of the patients with early stage NSCLC in the future. .
【中文题目：基于分子标志的非小细胞肺癌术后复发预测专家共识】 【中文摘要：近年来，肺癌在筛查、手术、放化疗、靶向治疗以及免疫治疗等各方面都取得了重大进展。目前手术切除仍是局限期非小细胞肺癌（non-small cell lung cancer, NSCLC）最重要的治疗方法，但仍有很多患者在术后5年内出现局部复发或远处转移。目前，NSCLC患者复发风险的评估主要基于临床及病理特征，并不能准确地区分不同复发风险的患者。随着新型检测手段的发展，已发现了多种可能在NSCLC中具有预测复发风险的分子标志。为归纳总结NSCLC患者术后复发相关的分子标志，我们制定了基于分子标志的NSCLC术后复发预测专家共识。共识主要围绕早期NSCLC患者，从分子层面对疾病复发风险进行探讨、归纳和总结。希望能够为早期NSCLC患者提供更多更有价值的预测复发风险工具，从而为疾病管理提供更多帮助。 】 【中文关键词：肺肿瘤；复发；分子标志；共识】.
Keywords: Consensus; Lung neoplasms; Molecular markers; Recurrence.