Efficacy of Scrambler Therapy for Management of Chronic Pain: A Meta-Analysis of Randomized Controlled Trials

Pain Physician. 2022 Oct;25(7):E931-E939.


Background: Although several randomized controlled trials (RCTs) have reported the efficacy of scrambler therapy (ST) for the management of chronic pain, those findings remain inconsistent.

Objectives: This meta-analysis aimed to investigate the efficacy of ST for the management of chronic pain.

Study design: A meta-analysis of RCTs.

Methods: We searched core databases including PubMed, EMBASE, and the Cochrane library for RCTs in October 2021. Standardized mean differences (SMDs) with 95% confidence intervals (CIs) for pain reduction were calculated using a random-effects model meta-analysis.

Results: Out of 348 studies, a total of 7 RCTs (n = 287 patients) that met the inclusion criteria were included in the final analysis. Overall, ST marginally decreased pain scores after the end of the treatment compared with the control group, with substantial heterogeneity (SMD, -0.85; 95% CI, -1.66 to -0.03; I2 = 89.5%, n = 7). A subgroup meta-analysis found that the use of ST significantly reduced analgesic consumption compared to the control group (SMD, -0.54; 95% CI, -0.93 to -0.14; I2 = 0.0%; n = 2). However, no significant efficacy was observed in the subgroup meta-analyses by methodological quality, type of diseases causing pain, and follow-up period.

Limitations: The included trials have a small sample size and low methodological quality.

Conclusions: ST seems to be effective in the management of patients with chronic pain. However, further, large RCTs are warranted to confirm our findings.

Keywords: Calmare therapy; chronic pain; meta-analysis; randomized controlled trials; Scrambler therapy.

Publication types

  • Meta-Analysis

MeSH terms

  • Chronic Pain* / therapy
  • Humans
  • Pain Management
  • Randomized Controlled Trials as Topic