Radiological manifestations of bisphosphonate treatment with APD in a child suffering from osteogenesis imperfecta

Skeletal Radiol. 1987;16(5):360-3. doi: 10.1007/BF00350961.


A 12-year-old female suffering from osteogenesis imperfecta (OI) was treated with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APD) orally, 250 mg daily, for periods of 2 months, alternating with periods of 2 months of abstinence. Total duration of therapy was 1 year. Radiological and clinical improvement was striking. Furthermore, X-rays of the bones showed large, parallel radio-opaque striae, corresponding exactly to the periods of therapy. These were present in all metaphyses.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Diphosphonates / therapeutic use*
  • Female
  • Follow-Up Studies
  • Humans
  • Osteogenesis Imperfecta / diagnostic imaging
  • Osteogenesis Imperfecta / drug therapy*
  • Pamidronate
  • Radiography


  • Diphosphonates
  • Pamidronate