Mitochondrial Dysfunction and Neurodegenerative Disorders: Role of Nutritional Supplementation

Int J Mol Sci. 2022 Oct 20;23(20):12603. doi: 10.3390/ijms232012603.


Mitochondrial dysfunction has been implicated in the pathogenesis of a number of neurodegenerative disorders, including Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, multisystem atrophy, and progressive supranuclear palsy. This article is concerned specifically with mitochondrial dysfunction as defined by reduced capacity for ATP production, the role of depleted levels of key nutritionally related metabolites, and the potential benefit of supplementation with specific nutrients of relevance to normal mitochondrial function in the above neurodegenerative disorders. The article provides a rationale for a combination of CoQ10, B-vitamins/NADH, L-carnitine, vitamin D, and alpha-lipoic acid for the treatment of the above neurodegenerative disorders.

Keywords: B-vitamins; alpha-lipoic acid; coenzyme Q10; l-carnitine; mitochondrial dysfunction; neurodegenerative disorders; selenium; vitamin D.

Publication types

  • Review

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Carnitine / metabolism
  • Dietary Supplements
  • Humans
  • Mitochondria / metabolism
  • Multiple System Atrophy* / metabolism
  • NAD / metabolism
  • Thioctic Acid* / metabolism
  • Thioctic Acid* / therapeutic use
  • Vitamin D / metabolism
  • Vitamins / metabolism
  • Vitamins / therapeutic use


  • NAD
  • Thioctic Acid
  • Vitamins
  • Carnitine
  • Vitamin D
  • Adenosine Triphosphate

Grants and funding

No funding was received.