Medicinal plants and natural compounds against acyclovir-resistant HSV infections

Lin Xu; Xuan-Lei Zhong; Zhi-Chao Xi; Yang Li; Hong-Xi Xu

doi:10.3389/fmicb.2022.1025605

Medicinal plants and natural compounds against acyclovir-resistant HSV infections

Front Microbiol. 2022 Oct 10:13:1025605. doi: 10.3389/fmicb.2022.1025605. eCollection 2022.

Authors

Lin Xu^{1

2}, Xuan-Lei Zhong^{1

2}, Zhi-Chao Xi^{1

2}, Yang Li^{1

2}, Hong-Xi Xu³

Affiliations

¹ School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
² Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, China.
³ Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Abstract

Herpes simplex virus (HSV), an alphaherpesvirus, is highly prevalent in the human population and is known to cause oral and genital herpes and various complications. Represented by acyclovir (ACV), nucleoside analogs have been the main clinical treatment against HSV infection thus far. However, due to prolonged and excessive use, HSV has developed ACV-resistant strains. Therefore, effective treatment against ACV-resistant HSV strains is urgently needed. In this review, we summarized the plant extracts and natural compounds that inhibited ACV-resistant HSV infection and their mechanism of action.

Keywords: acyclovir-resistant; antiviral herbs; herpes simplex virus; mode of action; natural products.

Publication types

Review