On interaction between fatigue of reconstruction plate and time-dependent bone remodeling

Boyang Wan; Nobuhiro Yoda; Keke Zheng; Zhongpu Zhang; Chi Wu; Jonathan Clark; Keiichi Sasaki; Michael Swain; Qing Li

doi:10.1016/j.jmbbm.2022.105483

On interaction between fatigue of reconstruction plate and time-dependent bone remodeling

J Mech Behav Biomed Mater. 2022 Dec:136:105483. doi: 10.1016/j.jmbbm.2022.105483. Epub 2022 Oct 4.

Authors

Boyang Wan¹, Nobuhiro Yoda², Keke Zheng³, Zhongpu Zhang⁴, Chi Wu⁵, Jonathan Clark⁶, Keiichi Sasaki⁷, Michael Swain⁸, Qing Li⁹

Affiliations

¹ School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, NSW, 2006, Australia. Electronic address: bwan9310@uni.sydney.edu.au.
² Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, 4-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 9808575, Japan. Electronic address: nobuhiro.yoda.e2@tohoku.ac.jp.
³ College of Engineering, Mathematics, and Physical Sciences, University of Exeter, EX4 4QF, United Kingdom. Electronic address: k.zheng@exeter.ac.uk.
⁴ School of Computing, Engineering and Mathematics, Western Sydney University, Penrith, NSW, 2751, Australia. Electronic address: leo.zhang@westernsydney.edu.au.
⁵ School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, NSW, 2006, Australia. Electronic address: chi.wu@sydney.edu.au.
⁶ Sydney Medical School, Faculty of Medicine and Health, The University of Sydney, NSW, 15, Australia. Electronic address: Jonathan.Clark@lh.org.au.
⁷ Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, 4-1, Seiryo-machi, Aoba-ku, Sendai, Miyagi, 9808575, Japan. Electronic address: keiichi.sasaki.e6@tohoku.ac.jp.
⁸ School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, NSW, 2006, Australia. Electronic address: michael.swain@sydney.edu.au.
⁹ School of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, NSW, 2006, Australia. Electronic address: qing.li@sydney.edu.au.

PMID: 36302272
DOI: 10.1016/j.jmbbm.2022.105483

Abstract

Background and objective: The fibula free flap (FFF) has been extensively used to repair large segmental bone defects in the maxillofacial region. The reconstruction plate plays a key role in maintaining stability and load-sharing while the fibula unites with adjacent bone in the course of healing and remodeling. However, not all fibula flaps would fully unite, and fatigue of prosthetic devices has been recognized as one major concern for long-term load-bearing applications. This study aims to develop a numerical approach for predicting the fatigue life of the reconstruction plate by taking into account the effect of ongoing bone remodeling.

Methods: The patient-specific mandible reconstruction with a prosthetic system is studied in this work. The 3D finite element model with heterogeneous material properties obtained from clinical computerized tomography (CT) data is developed for bone, and eXtended Finite Element Method (XFEM) is adopted for the fatigue analysis of the plate. During the remodeling process, the changing apparent density and Young's modulus of bone are simulated in a step-wise fashion on the basis of Wolff's law, which is correlated with the specific clinical follow-up. The maximum biting forces were considered as the driving force on the bone remodeling, which are measured clinically at different time points (4, 16 and 28 months) after reconstruction surgery.

Results: Under various occlusal loadings, the interaction between fatigue crack growth and bone remodeling is investigated to gain new insights for the future design of prosthetic devices. The simulation results reveal that appropriate remodeling of grafted bone could extend the fatigue life of fixation plates in a positive way. On the other hand, the rising occlusal load associated with healing and remodeling could lead to fatigue fracture of fixation plate and potentially cause severe bone resorption.

Conclusion: This study proposes an effective approach for more realistically predicting fatigue life of prosthetic devices subject to a tissue remodeling condition in-silico. It is anticipated to provide a guideline for deriving an optimal design of patient-specific prosthetic devices to better ensure longevity.

Keywords: Biomechanics; Bone remodeling; Fatigue fracture; Mandibular reconstruction plate; XFEM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bone Plates
Bone Remodeling
Fibula
Free Tissue Flaps* / transplantation
Humans
Mandible* / surgery
Mechanical Phenomena