Management Algorithm for Prevention of Mother-to-child Transmission of Hepatitis B Virus (2022)

Zhihua Liu; Zhongdan Chen; Fuqiang Cui; Yang Ding; Yunfei Gao; Guorong Han; Jidong Jia; Jie Li; Zengde Li; Yingxia Liu; Qing Mao; Ailing Wang; Wei Wang; Lai Wei; Jianhong Xia; Qing Xie; Xizhong Yang; Xueru Yin; Hua Zhang; Liaoyun Zhang; Wenhong Zhang; Hui Zhuang; Xiaoguang Dou; Jinlin Hou

doi:10.14218/JCTH.2022.00047

Management Algorithm for Prevention of Mother-to-child Transmission of Hepatitis B Virus (2022)

J Clin Transl Hepatol. 2022 Oct 28;10(5):1004-1010. doi: 10.14218/JCTH.2022.00047. Epub 2022 Jun 21.

Authors

Zhihua Liu¹, Zhongdan Chen², Fuqiang Cui³, Yang Ding⁴, Yunfei Gao⁵, Guorong Han⁶, Jidong Jia⁷, Jie Li⁸, Zengde Li⁹, Yingxia Liu¹⁰, Qing Mao¹¹, Ailing Wang¹², Wei Wang¹³, Lai Wei¹⁴, Jianhong Xia¹⁵, Qing Xie¹⁶, Xizhong Yang⁹, Xueru Yin¹, Hua Zhang¹⁷, Liaoyun Zhang¹⁸, Wenhong Zhang¹⁹, Hui Zhuang⁸, Xiaoguang Dou⁴, Jinlin Hou¹

Affiliations

¹ Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
² World Health Organization, Office of the WHO Representative in China, Beijing, China.
³ School of Public Health, Peking University, Beijing, China.
⁴ Department of Infectious Diseases, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China.
⁵ Department of Gynecology and Obstetrics, Zengcheng Branch of Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.
⁶ Department of Gynecology and Obstetrics, The Second Affiliated Hospital of the Southeast University, Nanjing, Jiangsu, China.
⁷ Liver Research Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
⁸ School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
⁹ Chinese Foundation for Hepatitis Prevention and Control, Beijing, China.
¹⁰ The Third People's Hospital of Shenzhen, Shenzhen, Guangdong, China.
¹¹ Department of Infectious Diseases, Southwest Hospital, Army Medical University, Chongqing, China.
¹² National Center for Women and Children's Health, China CDC, Beijing, China.
¹³ Department of Health Care, Shenzhen Baoan Women's and Children's Hospital, Shenzhen, Guangdong, China.
¹⁴ Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.
¹⁵ Guangdong Maternal and Child Health Hospital, Guangzhou, Guangdong, China.
¹⁶ Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
¹⁷ Department of Gynecology and Obstetrics, Beijing Youan Hospital, Capital Medical University, Beijing, China.
¹⁸ Department of Infectious Diseases, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
¹⁹ Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai, China.

Abstract

The World Health Organization (WHO) has set the goal of eliminating hepatitis as a threat to public health by 2030. Blocking mother-to-child transmission (MTCT) of hepatitis B virus (HBV) is not only the key to eliminating viral hepatitis, but also a hot issue in the field of hepatitis B prevention and treatment. To standardize the clinical management of preventing MTCT of HBV and achieve zero HBV infection among infants, the Chinese Foundation for Hepatitis Prevention and Control organized experts to compile a management algorithm for prevention of MTCT of HBV based on the latest research progress and guidelines, including 10 steps of pregnancy management and postpartum follow-up, among which screening, antiviral treatment, and infant immunization are its core components.

Keywords: Algorithm; Hepatitis B; Mother-to-child transmission.

Grants and funding

001/WHO_/World Health Organization/International