Four patients with pulmonary valve (PV) disease and patent foramen ovale (PFO) presented with dyspnea on exertion. Work-up revealed hypoxemia secondary to right-to-left intracardiac shunt. We demonstrate that correction of the primary culprit right heart overload lesion via PV replacement enabled safe PFO repair and resolution of hypoxemia.
Keywords: hypoxemia; patent foramen ovale; pulmonary valve regurgitation; pulmonary valve replacement; right ventricle; right-to-left intracardiac shunt; volume overload.
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