Long non-coding RNAs involved in retinoblastoma

J Cancer Res Clin Oncol. 2023 Jan;149(1):401-421. doi: 10.1007/s00432-022-04398-z. Epub 2022 Oct 28.

Abstract

Introduction: Retinoblastoma (RB) is the most common childhood tumor that can occur in the retina and develop in a sporadic or heritable form. Although various traditional treatment options have been used for patients with RB, identifying novel strategies for childhood cancers is necessary.

Material and methods: Recently, molecular-based targeted therapies have opened a greater therapeutic window for RB. Long non-coding RNAs (lncRNAs) presented a potential role as a biomarker for the detection of RB in various stages.

Conclusion: LncRNAs by targeting several miRNA/transcription factors play critical roles in the stimulation or suppression of RB. In this review, we summarized recent progress on the functions of tumor suppressors or oncogenes lncRNAs in RB.

Keywords: Biomarker; Long non-coding RNA; Oncogene; Retinoblastoma; Tumor suppressor.

Publication types

  • Review

MeSH terms

  • Biomarkers
  • Child
  • Humans
  • MicroRNAs* / genetics
  • RNA, Long Noncoding* / genetics
  • Retinal Neoplasms* / genetics
  • Retinal Neoplasms* / pathology
  • Retinoblastoma* / genetics
  • Retinoblastoma* / pathology

Substances

  • RNA, Long Noncoding
  • MicroRNAs
  • Biomarkers