Adding data to gut feelings

Benjamin J Marsland; Nicola L Harris

doi:10.1016/j.cell.2022.10.002

Adding data to gut feelings

Cell. 2022 Oct 27;185(22):4046-4048. doi: 10.1016/j.cell.2022.10.002.

Authors

Benjamin J Marsland¹, Nicola L Harris²

Affiliations

¹ Department of Immunology and Pathology, Central Clinical School, Monash University, The Alfred Research Alliance, Melbourne, VIC, Australia.
² Department of Immunology and Pathology, Central Clinical School, Monash University, The Alfred Research Alliance, Melbourne, VIC, Australia. Electronic address: nicola.harris@monash.edu.

PMID: 36306732
DOI: 10.1016/j.cell.2022.10.002

Abstract

Pain-sensing neurons detect environmental insults and tissue injury, driving avoidance behavior and the local release of neuropeptides. Two related papers in this issue of Cell report that gut-innervating pain neurons sense bacterial presence to both shape the constituents of the gut microbiome and protect against excessive inflammation.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Emotions
Gastrointestinal Microbiome*
Humans
Inflammation
Neuropeptides*
Pain

Substances

Neuropeptides