Outcome of the glucagon test depends upon the prevailing blood glucose concentration in type I (insulin-dependent) diabetic patients

Acta Med Scand. 1987;222(1):71-4. doi: 10.1111/j.0954-6820.1987.tb09931.x.


The outcome of 97 paired glucagon and meal tests was related to the prevailing fasting blood glucose concentrations on the two test days. At blood glucose concentration less than 7 mmol/l both the C-peptide responses and the maximal (6 min) C-peptide concentrations during the glucagon tests were significantly lower than the corresponding values found during the meal tests. During the glucagon tests, a direct relationship was found between the responsiveness of the pancreatic beta-cells and fasting blood glucose values when these were between 3 and 7 mmol/l. No significant difference was found between the outcome of the two tests when the fasting blood glucose concentration was greater than 7 mmol/l. The results indicate that the outcome of the glucagon test in Type I patients depends upon the prevailing fasting blood glucose concentration and that the predictive value of the glucagon test as to how the beta-cells will respond to a meal during everyday life is low when fasting blood glucose is less than 7 mmol/l.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Blood Glucose / analysis*
  • C-Peptide / blood
  • Diabetes Mellitus, Type 1 / blood*
  • Fasting
  • Female
  • Food
  • Glucagon*
  • Humans
  • Male


  • Blood Glucose
  • C-Peptide
  • Glucagon