Radiotherapy reimagined: Integrating nanomedicines into radiotherapy clinical trials

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2023 May-Jun;15(3):e1867. doi: 10.1002/wnan.1867. Epub 2022 Oct 28.


Radioenhancing nanoparticles (NPs) are being evaluated in ongoing clinical trials for various cancers including head and neck, lung, esophagus, pancreas, prostate, and soft tissue sarcoma. Supported by decades of preclinical investigation and recent randomized trial data establishing clinical activity, these agents are poised to influence future multimodality treatment paradigms involving radiotherapy. Although the physical interactions between NPs and ionizing radiation are well characterized, less is known about how these agents modify the tumor microenvironment, particularly regarding tumor immunogenicity. In this review, we describe the key multidisciplinary considerations related to radiation, surgery, immunology, and pathology for designing radioenhancing NP clinical trials. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease.

Keywords: dose enhancement; metal nanoparticles; nanoparticle; radiosensitizer.

Publication types

  • Review

MeSH terms

  • Humans
  • Lung
  • Male
  • Nanomedicine
  • Nanoparticles* / therapeutic use
  • Neoplasms* / drug therapy
  • Neoplasms* / radiotherapy
  • Tumor Microenvironment