Abstract
Formation of the PEN2-ATP6AP1 complex induced by the binding of metformin to PEN2 results in the inhibition of v-ATPase activity and in the recruitment of AXIN/LKB1 to lysosomes, which in turn results in the phosphorylation and activation of AMPK.
© 2022 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
MeSH terms
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AMP-Activated Protein Kinases / metabolism
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Humans
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Lysosomes / metabolism
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Metformin* / pharmacology
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Metformin* / therapeutic use
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Presenilins / metabolism
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Protein Serine-Threonine Kinases / metabolism
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Vacuolar Proton-Translocating ATPases* / metabolism
Substances
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Metformin
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Protein Serine-Threonine Kinases
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AMP-Activated Protein Kinases
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Presenilins
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ATP6AP1 protein, human
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Vacuolar Proton-Translocating ATPases