Low expression of DUSP4 expression predicts unfavorable prognosis in gallbladder adenocarcinoma

Indian J Pathol Microbiol. 2022 Oct-Dec;65(4):809-813. doi: 10.4103/ijpm.ijpm_352_21.


Background: Dual specificity phosphatase 4 (DUSP4), which regulates the mitogen activated protein kinases, has emerged as a tumor suppressor gene in several human malignancies.

Aims and objectives: In this study, we investigated the clinicopathologic significance and the prognostic role of DUSP4 in gallbladder adenocarcinoma. Materials and methods: DUSP4 expression was evaluated immunohistochemically in tissue microarray from 110 gallbladder adenocarcinoma samples and scored by H score system. The cut off (H score <170) was determined by ROC curve analysis. Results: Low expression of DUSP4 expression was observed in 57 (51.8%) out of 110 gallbladder adenocarcinoma samples. Low expression of DUSP4 expression was significantly associated with high histologic grade (P = 0.017), high pT stage (P = 0.002) and high AJCC stage (P = 0.007). Kaplan Meier survival curves revealed that patients with low expression of DUSP4 expression had significantly worse cancer specific survival (P = 0.024, log rank test). However, there was no significant association between DUSP4 expression and recurrence free survival.

Conclusions: In conclusion, gallbladder adenocarcinoma with low expression of DUSP4 expression was associated with adverse clinicopathologic characteristics and poor patient outcome.patient outcome.

Keywords: Dual-specificity phosphatase 4; gallbladder adenocarcinoma; immunohistochemistry; prognosis.

MeSH terms

  • Adenocarcinoma* / diagnosis
  • Adenocarcinoma* / genetics
  • Adenocarcinoma* / metabolism
  • Dual-Specificity Phosphatases / genetics
  • Dual-Specificity Phosphatases / metabolism
  • Gallbladder Neoplasms* / diagnosis
  • Gallbladder Neoplasms* / genetics
  • Gallbladder Neoplasms* / metabolism
  • Humans
  • Mitogen-Activated Protein Kinase Phosphatases / genetics
  • Prognosis


  • Dual-Specificity Phosphatases
  • DUSP4 protein, human
  • Mitogen-Activated Protein Kinase Phosphatases