Imaging of pediatric renal tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper focused on Wilms tumor and nephrogenic rests

Maddy Artunduaga; Meryle Eklund; Justine N van der Beek; Matthew Hammer; Annemieke S Littooij; Jesse K Sandberg; Jens-Peter Schenk; Sabah Servaes; Sudha Singh; Ethan A Smith; Abhay Srinavasan; Geetika Khanna

doi:10.1002/pbc.30004

Imaging of pediatric renal tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper focused on Wilms tumor and nephrogenic rests

Pediatr Blood Cancer. 2023 Jun;70 Suppl 4(Suppl 4):e30004. doi: 10.1002/pbc.30004. Epub 2022 Oct 29.

Authors

Maddy Artunduaga^{1

2}, Meryle Eklund³, Justine N van der Beek^{4

5}, Matthew Hammer^{1

2}, Annemieke S Littooij^{4

5}, Jesse K Sandberg⁶, Jens-Peter Schenk⁷, Sabah Servaes⁸, Sudha Singh⁹, Ethan A Smith^{10

11}, Abhay Srinavasan¹², Geetika Khanna¹³

Affiliations

¹ Pediatric Radiology Division, Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
² Children's Health Medical Center, Dallas, Texas, USA.
³ Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, South Carolina, USA.
⁴ Department of Radiology and Nuclear Medicine, University Medical Center Utrecht/Wilhelmina Children's Hospital, Utrecht University, Utrecht, The Netherlands.
⁵ Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
⁶ Department of Radiology, Stanford University School of Medicine, Stanford, California, USA.
⁷ Clinic of Diagnostic and Interventional Radiology, Division of Pediatric Radiology, Heidelberg University Hospital, Heidelberg, Germany.
⁸ Department of Radiology, West Virginia University Children's Hospital, Morgantown, West Virginia, USA.
⁹ Department of Radiology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
¹⁰ Department of Radiology, Cincinnati Children's Hospital, Cincinnati, Ohio, USA.
¹¹ Department of Radiology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
¹² Department of Radiology, Children's Hospital of Philadelphia, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
¹³ Department of Radiology & Imaging Sciences, Emory University, Children's Healthcare of Atlanta, Atlanta, Georgia, USA.

PMID: 36308415
PMCID: PMC10641878 (available on 2024-06-01)
DOI: 10.1002/pbc.30004

Abstract

Malignant renal tumors account for approximately 6% of pediatric malignancies, with Wilms tumor (WT) representing approximately 90% of pediatric renal tumors. This paper provides consensus-based imaging guidelines for the initial evaluation of a child with suspected WT and follow-up during and after therapy co-developed by the Children's Oncology Group (COG) Diagnostic Imaging and Society for Pediatric Radiology (SPR) oncology committees. The guidelines for Wilms Tumor Imaging in the Society of International Pediatric Oncology (SIOP) are briefly discussed to highlight some of the differences in imaging approach.

Keywords: Wilms tumors; children; computed tomography; magnetic resonance imaging; nephrogenic rests; radiology; renal masses; renal tumors; ultrasound.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Child
Humans
Kidney Neoplasms* / pathology
Radiography
Radiology*
Rest
Surface Plasmon Resonance
Wilms Tumor* / diagnostic imaging
Wilms Tumor* / pathology
Wilms Tumor* / therapy

Grants and funding

U10 CA180886/CA/NCI NIH HHS/United States