Profound Hypoglycemia With the Addition of a Tricyclic Antidepressant to Maintenance Sulfonylurea Therapy

Am J Psychiatry. 1987 Sep;144(9):1220-1. doi: 10.1176/ajp.144.9.1220.

Abstract

Cases of profound hypoglycemia after the initiation of tricyclic antidepressant therapy in two patients taking sulfonylureas are described. To the authors' knowledge, this is the first report of a potential drug interaction between tricyclic antidepressants and sulfonylureas.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Chlorpropamide / adverse effects*
  • Depressive Disorder / complications
  • Depressive Disorder / drug therapy
  • Diabetes Complications
  • Diabetes Mellitus / drug therapy
  • Doxepin / adverse effects*
  • Drug Interactions
  • Drug Therapy, Combination
  • Female
  • Humans
  • Hypoglycemia / chemically induced*
  • Middle Aged
  • Nortriptyline / adverse effects*
  • Tolazamide / adverse effects*

Substances

  • Doxepin
  • Tolazamide
  • Nortriptyline
  • Chlorpropamide