Ferroptosis in tumor immunity and therapy

J Cell Mol Med. 2022 Nov;26(22):5565-5579. doi: 10.1111/jcmm.17529. Epub 2022 Nov 1.


Ferroptosis is a type of regulated cell death (RCD), and it plays an important role in the occurrence of diseases, especially the development of tumors. Ferroptosis of tumor cells affects the antitumor immunity and the immune response to treatment to varying degrees. Ferroptosis also plays a key role in immune cells. This review outlines the mechanism of the immune-related effects of ferroptosis pathways in tumor progression and treatment, and it discusses potential methods for improving antitumor immunity and enhancing the efficacy of current cancer treatments by targeting ferroptosis.

Keywords: ferroptosis; immune; lipid peroxidation; therapy; tumor microenvironment.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ferroptosis*
  • Humans
  • Lipid Peroxidation
  • Neoplasms* / pathology