Serum Maresin 1 levels in idiopathic acute anterior uveitis patients

J Fr Ophtalmol. 2022 Dec;45(10):1160-1170. doi: 10.1016/j.jfo.2022.05.020. Epub 2022 Oct 29.

Abstract

Purpose: The purpose of the present study is to assess the levels of Maresin 1 (MaR1) in patients with idiopathic acute anterior uveitis (IAAU) and to compare the MaR1 results with healthy controls.

Methods: This study includes 24 patients with idiopathic AAU and 24 healty controls (C). The serum MaR1 levels were analyzed using enzyme-linked immunosorbent assays (ELISA). The erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels were measured at the time of diagnosis.

Results: MaR1 levels were statistically significant when the IAAU group was compared with group C (P<0.001). When idiopathic AAU patients were compared with group C, no statistically significant difference was found between ESR and CRP levels (P=0.086, P=0.549 respectively).

Conclusion: Serum MaR1 levels are an important biomarker of disease in patients with idiopathic AAU.

Keywords: CRP; ESR; Idiopathic; Idiopathique; Maresin; Marésine; Uveitis; Uvéite.

MeSH terms

  • Biomarkers
  • Docosahexaenoic Acids
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Uveitis, Anterior* / diagnosis

Substances

  • 7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid
  • Docosahexaenoic Acids
  • Biomarkers