Glutathione Component of Antioxidant Status in Menopausal Women with Insomnia

Bull Exp Biol Med. 2022 Oct;173(6):775-778. doi: 10.1007/s10517-022-05628-7. Epub 2022 Nov 2.


The study involved 138 women aged 45-60 years in perimenopause (n=55) and postmenopause (n=83) with insomnia (main groups) and without it (control). The levels of reduced (GSH) and oxidized (GSSG) glutathione and glutathione peroxidase activity were determined in erythrocytes; activities of glutathione S-transferase and glutathione reductase were measured in blood serum. The differences with the control groups were found only in perimenopause: higher glutathione reductase activity and reduced GSSG level and GSH/GSSG ratio in women with insomnia (p<0.05). The results of the comparative analysis between the main groups showed lower glutathione reductase activity, increased GSSG level, and a decrease the GSH/GSSG ratio in the postmenopausal period compared with the perimenopause (p<0.05). These results can be used in choosing the tactics for complex therapy of insomnia in menopausal women to correct free radical homeostasis and prevention of oxidative stress.

Keywords: glutathione; glutathione S-transferase; glutathione peroxidase; glutathione reductase; menopause.

MeSH terms

  • Antioxidants* / metabolism
  • Female
  • Glutathione / metabolism
  • Glutathione Disulfide
  • Glutathione Peroxidase / metabolism
  • Glutathione Reductase / metabolism
  • Glutathione Transferase / metabolism
  • Humans
  • Menopause
  • Oxidative Stress
  • Sleep Initiation and Maintenance Disorders*


  • Antioxidants
  • Glutathione Reductase
  • Glutathione Disulfide
  • Glutathione Peroxidase
  • Glutathione
  • Glutathione Transferase