[Pathology and pathogenesis of HIV encephalopathy]

S M Liu; Y M Niu; W M Tong

doi:10.3760/cma.j.cn112151-20220328-00328

[Pathology and pathogenesis of HIV encephalopathy]

Zhonghua Bing Li Xue Za Zhi. 2022 Nov 8;51(11):1186-1188. doi: 10.3760/cma.j.cn112151-20220328-00328.

[Article in Chinese]

Authors

S M Liu¹, Y M Niu², W M Tong²

Affiliations

¹ Department of Pathology, Institute of Basic Medical Sciences, Molecular Pathology Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China Department of Pathology, College of Basic Medical Science, China Medical University, Shenyang 110122, China.
² Department of Pathology, Institute of Basic Medical Sciences, Molecular Pathology Research Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China.

PMID: 36323557
DOI: 10.3760/cma.j.cn112151-20220328-00328

Abstract

艾滋病，即获得性免疫缺陷综合征（acquired immunodeficiency syndrome，AIDS），其主要特征为CD4阳性淋巴细胞数量显著减少，引起机体免疫功能不足，继而引发各种条件致病菌感染以及肿瘤等疾病，最终导致患者死亡。其中，艾滋病患者常伴发中枢神经系统感染，即艾滋病脑病，其典型的病理特征是血管周围有大量炎性细胞浸润，其发病机制可能是人类免疫缺陷病毒本身及其分泌的蛋白引起神经系统炎症反应并导致神经元继发性损伤，但艾滋病脑病确切的发病机制仍有待进一步深入探究。.

MeSH terms

AIDS Dementia Complex* / pathology
HIV Infections*
Humans