Orexin neuropeptides modulate the hippocampal-dependent memory through basolateral amygdala interconnections

Mahdi Abounoori; Mohammad Moein Maddah; Motahareh Rouhi Ardeshiri

doi:10.1016/j.cccb.2021.100035

Orexin neuropeptides modulate the hippocampal-dependent memory through basolateral amygdala interconnections

Cereb Circ Cogn Behav. 2021 Dec 31:3:100035. doi: 10.1016/j.cccb.2021.100035. eCollection 2022.

Authors

Mahdi Abounoori¹, Mohammad Moein Maddah¹, Motahareh Rouhi Ardeshiri^{2

3}

Affiliations

¹ Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
² Immunogenetics Research Center, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
³ Department of Physiology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Abstract

Orexin neuropeptides have functional roles in hippocampal-dependent memory formation via the consolidation and retrieval of passive avoidance and spatial memories. The effects of these neuropeptides have been confirmed on the induction of long-term potentiation (LTP). The orexinergic system seems to have modulatory effects by sending projection fibers to several brain parts, such as the hippocampus and amygdala. Orexin neuropeptides activate the neural circuits of the basolateral amygdala during different arousal events with various emotional loads. Therefore, this system plays a vital role in creating appropriate behavioral reactions and responses particular to the situation. This review aimed to report new progression and advances in the hippocampus function in memory by focusing on its relationship with the amygdala through the orexinergic system.

Keywords: Basolateral amygdala; Hippocampus; Orexin neuropeptides.

Publication types

Review