Abstract
Membranes isolated from the red cells of a Hb-Koln patient were shown to contain appreciable amounts of N epsilon-(gamma-glutamyl)lysine, the characteristic product of the post-translational cross-linking of proteins by transglutaminase. Such an apparently irreversible fusion of membrane proteins may contribute to the membrane defect in Hb-Koln disease.
Publication types
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Case Reports
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adult
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Centrifugation, Density Gradient
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Chromatography, High Pressure Liquid
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Dipeptides / blood*
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Erythrocyte Membrane / metabolism*
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Female
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Hemoglobinopathies / blood*
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Hemoglobins, Abnormal / metabolism*
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Humans
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Membrane Proteins / blood*
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Polymers
Substances
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Dipeptides
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Hemoglobins, Abnormal
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Membrane Proteins
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Polymers
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epsilon-(gamma-glutamyl)-lysine
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hemoglobin Koln