Fetal Repair of Neural Tube Defects

Su Yeon Lee; Ramesha Papanna; Diana Farmer; KuoJen Tsao

doi:10.1016/j.clp.2022.06.004

Fetal Repair of Neural Tube Defects

Clin Perinatol. 2022 Dec;49(4):835-848. doi: 10.1016/j.clp.2022.06.004. Epub 2022 Oct 9.

Authors

Su Yeon Lee¹, Ramesha Papanna², Diana Farmer³, KuoJen Tsao⁴

Affiliations

¹ Department of Surgery, Division of Pediatric, Thoracic and Fetal Surgery, University of California Davis Medical Center, 2335 Stockton Boulevard, Room 5107, Sacramento, CA 95817, USA. Electronic address: suyle@ucdavis.edu.
² Department of Obstetrics, Gynecology and Reproductive Sciences, UT Health Science Center at Houston, 6410 Fannin Street, Suite 210, Houston, TX 77030, USA.
³ Department of Surgery, University of California Davis Medical Center, 2335 Stockton Boulevard, Sacramento, CA 95817, USA.
⁴ Department of Pediatric Surgery, UT Health Science Center at Houston, 6410 Fannin Street, Suite 950, Houston, TX 77030, USA.

PMID: 36328602
DOI: 10.1016/j.clp.2022.06.004

Abstract

Myelomeningocele is the most common congenital neurologic defect, and the only nonlethal disease addressed by fetal surgery. A randomized control trial has established amelioration of the Arnold-Chiari II malformation, reduced ventriculoperitoneal shunt rate, and improvement in distal neurologic function in patients that receive in utero repair. Long-term follow-up of these school-age children demonstrates the persistence of these effects. The use of stem cells in fetal repair is being investigated to further improve distal motor function.

Keywords: MOMS trial; Myelomeningocele; Open neural tube defect; Spina bifida.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Child
Female
Fetal Therapies*
Fetus / surgery
Humans
Meningomyelocele* / surgery
Neural Tube Defects* / surgery
Pregnancy
Prenatal Care
Randomized Controlled Trials as Topic