Context is key: Modulated protein multivalency in disease

Mol Cell. 2022 Nov 3;82(21):3965-3967. doi: 10.1016/j.molcel.2022.10.011.


In this issue of Molecular Cell, Song et al. demonstrate that mutations to the YEATS domain of ENL aberrantly activate gene expression by forming condensates on specific genomic loci. By using diverse experimental approaches, the authors dissect the molecular underpinnings of ENL mutant condensate formation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Protein Domains
  • Transcription Factors* / metabolism
  • Transcriptional Elongation Factors* / genetics


  • Transcriptional Elongation Factors
  • Transcription Factors