Environmental Risks for Spondyloarthropathies

Rheum Dis Clin North Am. 2022 Nov;48(4):813-826. doi: 10.1016/j.rdc.2022.06.004.

Abstract

Spondyloarthropathies, also known as spondyloarthritis, encompasses a spectrum of diseases classified by it's axial and peripheral musculoskeletal manifestations. Extra-articular features are common in SpA making these systemic rheumatologic diseases involve the skin, eye, gut, and other organ systems.Research has identified risk factors for the development of spondyloarthritis, particularly regarding genetic susceptibility and the strong association with HLA-B27. Multiple studies have elucidated clinical risk factors associated with SpA disease activity and severity. In this review, we aim to explore the environmental risk factors for spondyloarthritis.

Keywords: Ankylosing spondylitis; Psoriatic arthritis; Reactive arthritis; Risk factors; Spondyloarthritis.

Publication types

  • Review

MeSH terms

  • HLA-B27 Antigen / genetics
  • Humans
  • Spondylarthritis* / complications
  • Spondylarthritis* / genetics
  • Spondylarthropathies* / genetics
  • Spondylitis, Ankylosing* / complications

Substances

  • HLA-B27 Antigen