Modular Peptide Probe for Protein Analysis

Chemistry. 2023 Feb 10;29(9):e202203225. doi: 10.1002/chem.202203225. Epub 2022 Dec 8.


The analysis and regulation of proteins are of great significance for the development of disease diagnosis and treatment. However, complicated analytical environment and complex protein structure severely limit the accuracy of their analysis results. Nowadays, ascribing to the editability and bioactivity of peptides, peptide-based probes could meet the requirements of good selectivity and high affinity to overcome the challenges. In this review, we summarize the advances in the use of modular peptide probes for proteins analysis. It focuses on how to design and optimize the structure of probes, as well as their performance. Then, the strategies and application to improve the analysis result of modular peptide probes are introduced. Finally, we also discuss current challenge and provide some ideas for the future direction for modular peptide probes, hoping to accelerate their clinical transformation.

Keywords: aggregation-induced emission; fluorescent probes; living cells; peptides; protein analysis.

Publication types

  • Review

MeSH terms

  • Fluorescent Dyes* / chemistry
  • Peptides* / chemistry
  • Proteins


  • Fluorescent Dyes
  • Peptides
  • Proteins