An NTRK-1-associated soft tissue tumor showing distinctive nodules with peripheral accentuation of cellularity

J Cutan Pathol. 2023 Apr;50(4):343-348. doi: 10.1111/cup.14355. Epub 2022 Nov 23.


Lipofibromatosis-like neural tumor is a recently described entity defined by a low-cellularity spindle cell infiltrate in the subcutaneous fat with admixed inflammatory cells. This tumor is histopathologically similar to lipofibromatosis, but unlike lipofibromatosis shows reactivity for S100 and has an NTRK-1 kinase fusion. These lesions are locally aggressive but appear to have a negligible metastatic potential. Subsequently, a more cellular variant has been described with generally low mitotic rate. This variant also displays S100 reactivity and kinase fusions (typically involving NTRK-1), but it has a low risk of metastasis. In this report, we describe a case that aligns with the more cellular variant of NTRK-1 kinase fusion tumors on histopathologic, immunohistochemical, and molecular grounds, but in addition has distinctive nodules with peripheral accentuation of cellularity, reminiscent of those present in epithelioid malignant peripheral nerve sheath tumors. This latter feature is previously undescribed in NTRK kinase fusion soft tissue tumors and offers further support for the presumed neural differentiation of this neoplasm.

Keywords: NTRK; lipofibromatosis-like neural tumor; malignant peripheral nerve sheath tumor.

MeSH terms

  • Biomarkers, Tumor
  • Breast Neoplasms*
  • Female
  • Humans
  • Receptor, trkA / genetics
  • Skin Neoplasms* / genetics
  • Soft Tissue Neoplasms* / pathology


  • Receptor, trkA
  • Biomarkers, Tumor