Recent update of the various sources originating ghost peaks in gas chromatography: A review

Anuj Kumar; Chhaya Sharma

doi:10.1016/j.chroma.2022.463625

Recent update of the various sources originating ghost peaks in gas chromatography: A review

J Chromatogr A. 2022 Dec 6:1685:463625. doi: 10.1016/j.chroma.2022.463625. Epub 2022 Oct 30.

Authors

Anuj Kumar¹, Chhaya Sharma²

Affiliations

¹ GC-MS Laboratory, Department of Paper Technology, Indian Institute of Technology Roorkee, Saharanpur Campus, Saharanpur, Uttar Pradesh, 247001, India.
² GC-MS Laboratory, Department of Paper Technology, Indian Institute of Technology Roorkee, Saharanpur Campus, Saharanpur, Uttar Pradesh, 247001, India. Electronic address: chhaya.sharma@pt.iitr.ac.in.

PMID: 36335908
DOI: 10.1016/j.chroma.2022.463625

Abstract

Gas chromatography (GC) is a versatile tool for separating various volatile, semi-volatile, and thermally stable compounds. However, the ghost peaks in the GC are now a major concern for chromatographic analysts. Ghost peaks may interfere with the analyte, leading to inaccurate results, so identifying the sources generating these peaks is essential for the validated analysis of the compounds of interest. This review compiles various sources responsible for generating ghost peaks in the GC and their possible troubleshooting methods for the smooth and consistent running of the ghost peak-free gas chromatography system, which will be very helpful for rapid and validated analysis.

Keywords: Artifacts; Gas chromatography; Ghost peaks; Septa; Siloxanes.

Publication types

Review

MeSH terms

Chromatography, Gas* / methods