A nanoporous gold film sensor modified with polypyrrole/CuO nanocomposite for electrochemical determination of piroxicam and tramadole

Mehrnoosh Sadeghi; Mehdi Shabani-Nooshabadi; Hanieh Ansarinejad

doi:10.1016/j.envres.2022.114633

A nanoporous gold film sensor modified with polypyrrole/CuO nanocomposite for electrochemical determination of piroxicam and tramadole

Environ Res. 2023 Jan 1;216(Pt 3):114633. doi: 10.1016/j.envres.2022.114633. Epub 2022 Nov 4.

Authors

Mehrnoosh Sadeghi¹, Mehdi Shabani-Nooshabadi², Hanieh Ansarinejad¹

Affiliations

¹ Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R, Iran.
² Department of Analytical Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R, Iran; Institute of Nano Science and Nano Technology, University of Kashan, Kashan, P.O. Box 87317-51167, I.R, Iran. Electronic address: m.shabani@kashanu.ac.ir.

PMID: 36343714
DOI: 10.1016/j.envres.2022.114633

Abstract

In this paper, an electrochemical sensor was developed to determine piroxicam (PX) and tramadole (Tr) based on their enhanced electrochemical responses at the surface of the polypyrrole/CuO nanocomposite-modified nanoporous gold film (NPGF) electrode. The experimental results showed that PX provide an oxidation peak at 0.65 V in pH = 8.0. The DPV results were linearly affiliated on PX concentration within the two closed windows (C1_PX = 0.05-30.0 μM, correlation coefficient of 0.9905, and C2_PX = 50.0-300.0 μM, correlation coefficient of 0.9927). From voltammetric curves, the detection limit (LOD = 3S_b/m) for PX at a surface of PPY-CuO-NPGF electrode was appeared to be 0.01 μM. Furthermore, the ability of PPY-CuO-NPGF electrode for simultaneous measurement of PX and Tr was investigated. The suggested sensor shows a long-time stability, good repeatability, and rapid response in the mixture media of PX and Tr.

Keywords: Electrochemical determination; Nanoporous gold film; Piroxicam; Tramadole.

MeSH terms

Electrochemical Techniques / methods
Gold
Nanocomposites*
Nanopores*
Piroxicam
Polymers
Pyrroles

Substances

Gold
polypyrrole
Polymers
cupric oxide
Pyrroles
Piroxicam