Associations of five obesity indicators with cognitive performance in 30,697 Taiwan Biobank participants

doi:10.1186/s12877-022-03457-x

. 2022 Nov 7;22(1):839.

doi: 10.1186/s12877-022-03457-x.

Associations of five obesity indicators with cognitive performance in 30,697 Taiwan Biobank participants

Wan-Yu Lin^{1

2

3}

Affiliations

¹ Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. linwy@ntu.edu.tw.
² Master of Public Health Degree Program, College of Public Health, National Taiwan University, Taipei, Taiwan. linwy@ntu.edu.tw.
³ Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan. linwy@ntu.edu.tw.

PMID: 36344931
PMCID: PMC9641815
DOI: 10.1186/s12877-022-03457-x

Associations of five obesity indicators with cognitive performance in 30,697 Taiwan Biobank participants

Wan-Yu Lin. BMC Geriatr. 2022.

. 2022 Nov 7;22(1):839.

doi: 10.1186/s12877-022-03457-x.

Author

Wan-Yu Lin^{1

2

3}

Affiliations

¹ Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan. linwy@ntu.edu.tw.
² Master of Public Health Degree Program, College of Public Health, National Taiwan University, Taipei, Taiwan. linwy@ntu.edu.tw.
³ Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan. linwy@ntu.edu.tw.

PMID: 36344931
PMCID: PMC9641815
DOI: 10.1186/s12877-022-03457-x

Abstract

Background: Obesity adversely influences the central nervous system and cognitive functions. However, the relationship between various obesity indicators and cognitive performance remains controversial. It is unclear which obesity indicator is more relevant to cognitive impairment.

Methods: The Taiwan Biobank (TWB) administered the Chinese version of the Mini-Mental State Examination (MMSE) to 30,697 participants (12,094 males and 18,603 females) aged 60 to 70 years. A total of 3,454 (11.25%) individuals with MMSE < = 24 were classified as having poor cognitive performance. This cross-sectional study investigates the associations of five obesity indicators with cognitive performance. Five separate logistic regression models were fitted for males and another five for females. Covariates adjusted in all models included age, smoking status, drinking status, regular exercise, chronic disease status (diabetes, cardiovascular diseases, heart diseases, stroke, or Parkinson's disease), depression status, blood pressure level, total cholesterol, fasting glucose, and educational attainment. The five obesity indicators included body mass index (BMI), body fat percentage (BFP), waist circumference (WC), hip circumference (HC), and waist-hip ratio (WHR).

Results: Abdominal obesity defined by WHR was significantly associated with poor cognitive performance. Male WHR > = 0.90 had a higher risk of poor cognitive performance than male WHR < 0.90 (odds ratio [OR] = 1.233; p = 0.007); female WHR > = 0.85 had an increased risk of poor cognitive performance compared with female WHR < 0.85 (OR = 1.221; p = 3.9E-4). HC and general obesity (defined by BMI and BFP) were not significantly associated with cognitive performance.

Conclusion: The results consistently agreed that preventing abdominal obesity is associated with better cognitive performance in both males and females.

Keywords: Abdominal obesity; Dementia; Mini-mental state examination.

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Conflict of interest statement

The author declares that she has no competing interests.

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References

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[1] 1. Fredriksen-Goldsen KI, Jen S, Bryan AEB, Goldsen J: Cognitive Impairment, Alzheimer’s Disease, and Other Dementias in the Lives of Lesbian, Gay, Bisexual and Transgender (LGBT) Older Adults and Their Caregivers: Needs and Competencies. J Appl Gerontol 2018, 37(5):545–569. - PMC - PubMed

[2] 1. Fredriksen-Goldsen KI, Jen S, Bryan AEB, Goldsen J: Cognitive Impairment, Alzheimer’s Disease, and Other Dementias in the Lives of Lesbian, Gay, Bisexual and Transgender (LGBT) Older Adults and Their Caregivers: Needs and Competencies. J Appl Gerontol 2018, 37(5):545–569. - PMC - PubMed

[3] 2. Plassman BL, Langa KM, McCammon RJ, Fisher GG, Potter GG, Burke JR, Steffens DC, Foster NL, Giordani B, Unverzagt FW et al: Incidence of dementia and cognitive impairment, not dementia in the United States. Ann Neurol 2011, 70(3):418–426. - PMC - PubMed

[4] 2. Plassman BL, Langa KM, McCammon RJ, Fisher GG, Potter GG, Burke JR, Steffens DC, Foster NL, Giordani B, Unverzagt FW et al: Incidence of dementia and cognitive impairment, not dementia in the United States. Ann Neurol 2011, 70(3):418–426. - PMC - PubMed

[5] 3. Pais R, Ruano L, O PC, Barros H: Global Cognitive Impairment Prevalence and Incidence in Community Dwelling Older Adults-A Systematic Review. Geriatrics (Basel) 2020, 5(4). - PMC - PubMed

[6] 3. Pais R, Ruano L, O PC, Barros H: Global Cognitive Impairment Prevalence and Incidence in Community Dwelling Older Adults-A Systematic Review. Geriatrics (Basel) 2020, 5(4). - PMC - PubMed

[7] 4. Arevalo-Rodriguez I, Smailagic N, Roque-Figuls M, Ciapponi A, Sanchez-Perez E, Giannakou A, Pedraza OL, Bonfill Cosp X, Cullum S: Mini-Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev 2021, 7:CD010783. - PMC - PubMed

[8] 4. Arevalo-Rodriguez I, Smailagic N, Roque-Figuls M, Ciapponi A, Sanchez-Perez E, Giannakou A, Pedraza OL, Bonfill Cosp X, Cullum S: Mini-Mental State Examination (MMSE) for the early detection of dementia in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev 2021, 7:CD010783. - PMC - PubMed

[9] 5. Folstein MF, Folstein SE, McHugh PR: “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975, 12(3):189–198. - PubMed

[10] 5. Folstein MF, Folstein SE, McHugh PR: “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975, 12(3):189–198. - PubMed

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Associations of five obesity indicators with cognitive performance in 30,697 Taiwan Biobank participants

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Associations of five obesity indicators with cognitive performance in 30,697 Taiwan Biobank participants

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