SPR Based Biosensing Chip for COVID-19 Diagnosis-A Review

IEEE Sens J. 2022 Jun 14;22(14):13800-13810. doi: 10.1109/JSEN.2022.3181423. eCollection 2022 Jul.


Surface Plasmon Resonance (SPR) techniques are highly accurate in detecting biomolecular like blood group measurement, food adulteration, milk adulteration and recently developing as a rapid detection for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. In order to validate the clinical diagnosis, Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) of nasopharyngeal swabs has been utilized, which is time consuming and expensive. For fast and accurate detection of the SARS-CoV-2 virus, SPR based biosensing chips are described in this review article. SPR sensors have the potential to be employed for fast, accurate, and portable SARS-CoV-2 virus diagnosis. To combat the SARS-CoV-2 pandemic, there is considerable interest in creating innovative biosensors that are quick, reliable, and sensitive for COVID-19 diagnosis.

Keywords: 2-D materials; Kretschmann configuration; SARS-CoV-2; Surface plasmon resonance; biosensor.

Grants and funding

This work was supported by the Central Scientific Instruments Organisation (CSIR), Chandigarh, India, through the Project “Design and Development of Deployable Thin Film-Based Evanescent Field Sensor to Check the Quality of Food From Adulteration” under Sanction 70(0077)/19/EMR-II [CSIR(32)/2019-2020/663/ECE]. The work of Santosh Kumar was supported by the Double-Hundred Talent Plan of Shandong Province, China.