The Impact of COVID-19 Lockdown on Glycemic Balance in Romanian Patients with Type 1 Diabetes Mellitus

Adriana Gherbon; Mirela Frandes; Romulus Timar; Bogdan Timar

doi:10.2147/DMSO.S386614

The Impact of COVID-19 Lockdown on Glycemic Balance in Romanian Patients with Type 1 Diabetes Mellitus

Diabetes Metab Syndr Obes. 2022 Nov 2:15:3403-3413. doi: 10.2147/DMSO.S386614. eCollection 2022.

Authors

Adriana Gherbon^{1

2}, Mirela Frandes³, Romulus Timar^{1

2}, Bogdan Timar^{1

2}

Affiliations

¹ Second Department of Internal Medicine - Diabetes, Nutrition and Metabolic Diseases, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.
² Department of Diabetes and Metabolic Diseases, "Pius Brinzeu" Emergency Hospital, Timisoara, Romania.
³ Department of Functional Sciences - Medical Informatics and Biostatistics, "Victor Babes" University of Medicine and Pharmacy, Timisoara, Romania.

Abstract

Introduction: The COVID-19 pandemic has brought major changes not only at the economic and social level but especially in the medical system.

Objective: To evaluate the impact of COVID-19 lockdown on the quality of glycemic control in Romanian patients with type 1 diabetes mellitus (T1DM).

Material and method: Our study group included 102 Romanian volunteers' patients with T1DM from both urban and rural areas. Data were collected during an interview, based on a structured questionnaire with multiple-choice questions about diabetes management during lockdown, how they interact with their diabetologist, how they accessed the treatment and what other factors influenced their diabetes management during the lockdown.

Results: Blood glucose levels were significantly higher in the MDII group as a consequence of delayed administration of insulin corrections due to inadequate insulin dosing (60% vs 31.81%; χ ² = 5.51, p = 0.018). In addition, insulin pump users had improved response to stress and anxiety (ie, additional therapeutic safety being provided by use of insulin pump; in some devices, blood glucose being continuously monitored, leading to premature detection of important blood glucose excursions) compared to insulin pen users (χ ² = 5.09, p = 0.024). In the context of hypoglycemia, we observed that in the pen MDII group, more users have administered an excess of insulin, compared with the pump users (80% vs 45.45%; χ ² = 10.34; p = 0.001).

Conclusion: A lower impact of COVID-19 lockdown on glycemic control was observed in patients with T1DM treated using insulin pumps compared to patients with T1DM who administered their insulin using insulin pens. Telemedicine and online consultations have brought significant improvements in diseases management. Stress, emotions, and anxiety were among the main reasons that led to increases in blood sugar levels, suggesting that the psychological impact may have long-term complications.

Keywords: COVID-19; diabetes management; insulin pumps; lockdown; type 1 diabetes mellitus.