Enzyme-Treated Caviar Prevents UVB Irradiation-Induced Skin Photoaging

Mar Drugs. 2022 Oct 30;20(11):685. doi: 10.3390/md20110685.

Abstract

For this research article, we investigated the protective effects of enzyme-treated caviar powder extract (CV) in ultraviolet B (UVB)-irradiated hairless mice and keratinocytes by confirming moisturizing-related factors and elasticity-related factors. UVB irradiation induced wrinkle formation, dehydration, oxidative stress, and inflammation in the dorsal skin of mice; however, these were suppressed in the CV-supplemented groups in UVB-irradiated hairless mice. Furthermore, in UVB-irradiated keratinocytes, CV treatment increased the antioxidant enzyme activities and the levels of sphingomyelin and hyaluronic acid and decreased the production of pro-inflammatory cytokines and the expression of IkB-α and p65 phosphorylation. These findings indicate that CV can directly protect keratinocytes against UVB irradiation-induced oxidative stress and inflammation. Therefore, we suggest that CV can protect against UVB-induced skin photoaging. Therefore, we suggest that caviar is effective for skin health by preventing UVB-induced skin photoaging.

Keywords: UVB; caviar; oxidative stress; skin photoaging.

MeSH terms

  • Animals
  • Antioxidants / metabolism
  • Antioxidants / pharmacology
  • Inflammation / metabolism
  • Keratinocytes
  • Mice
  • Mice, Hairless
  • Skin / radiation effects
  • Skin Aging*
  • Ultraviolet Rays / adverse effects

Substances

  • Antioxidants

Grants and funding

This research received no external funding.