MicroRNAs in esophageal squamous cell carcinoma: Application in prognosis, diagnosis, and drug delivery

Pathol Res Pract. 2022 Dec:240:154196. doi: 10.1016/j.prp.2022.154196. Epub 2022 Nov 2.


MicroRNAs (miRNAs) play a vital role in various cell biology processes, including cancer formation. These small non-coding RNAs could function as diagnostic and prognostic markers. They may involve esophageal squamous cell carcinoma (ESCC) and distinctive miRNA expression profiles; they are also known as therapeutic targets in human diseases. Therefore, in this study, the function of miRNAs was reviewed regarding the prognosis and diagnosis of ESCC. The changes in miRNAs before and after cancer therapy and the effects of miRNAs on chemo-susceptibility patterns were also investigated. MiRNA delivery systems in ESCC were also highlighted, providing a perspective on how these systems can improve miRNA efficiency.

Keywords: Cancer therapy; Delivery system; Esophageal squamous cell carcinoma; MicroRNAs.

Publication types

  • Review

MeSH terms

  • Biomarkers, Tumor / genetics
  • Esophageal Neoplasms* / diagnosis
  • Esophageal Neoplasms* / genetics
  • Esophageal Neoplasms* / pathology
  • Esophageal Squamous Cell Carcinoma* / genetics
  • Esophageal Squamous Cell Carcinoma* / pathology
  • Gene Expression Regulation, Neoplastic / genetics
  • Humans
  • MicroRNAs* / genetics
  • MicroRNAs* / metabolism
  • Prognosis


  • MicroRNAs
  • Biomarkers, Tumor