CircRNAs in Tumor Radioresistance

Biomolecules. 2022 Oct 28;12(11):1586. doi: 10.3390/biom12111586.


Circular RNAs (circRNAs) are endogenous, non-coding RNAs, which are derived from host genes that are present in several species and can be involved in the progression of various diseases. circRNAs' leading role is to act as RNA sponges. In recent years, the other roles of circRNAs have been discovered, such as regulating transcription and translation, regulating host genes, and even being translated into proteins. As some tumor cells are no longer radiosensitive, tumor radioresistance has since become a challenge in treating tumors. In recent years, circRNAs are differentially expressed in tumor cells and can be used as biological markers of tumors. In addition, circRNAs can regulate the radiosensitivity of tumors. Here, we list the mechanisms of circRNAs in glioma, nasopharyngeal carcinoma, and non-small cell lung cancer; further, these studies also provide new ideas for the purposes of eliminating radioresistance in tumors.

Keywords: circular RNAs; miRNAs; radiation therapy; radioresistance; tumor.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Non-Small-Cell Lung*
  • Humans
  • Lung Neoplasms* / genetics
  • Nasopharyngeal Neoplasms*
  • RNA / metabolism
  • RNA, Circular / genetics


  • RNA, Circular
  • RNA

Grant support

This research was funded by [the National Natural Science Foundation of China] grant number [81872557] and [science and technology projects in Guangzhou] grant number [202201011800].