Effects of Grape Seed Extract Supplementation on Endothelial Function and Endurance Performance in Basketball Players

Int J Environ Res Public Health. 2022 Oct 31;19(21):14223. doi: 10.3390/ijerph192114223.


While dietary polyphenols supplements can improve endothelial function and blood flow to exercise, the effects of chronic supplementation with grape seed extract (GSE) containing a high dose of polyphenols on endurance performance are not known. Accordingly, in 12 elite athletes, we compared the effects of both GSE and placebo (PL) on submaximal VO2, time to exhaustion performance, and endothelial function during progressive cycling exercise for 14 days. Endothelial function was evaluated from the brachial artery via flow-mediated dilation (FMD). Compared to PL, GSE decreased submaximal VO2 at 80% and 120% of VO2peak and increased the time to exhaustion (p < 0.05). GSE also resulted in FMD-induced increase in brachial artery diameter (14.4 ± 5.2% vs. 17.6 ± 4.5%, p = 0.035). We demonstrated that chronic supplementation with GSE improved endurance performance and these effects may partially be due to vasodilation in active skeletal muscle mediated by enhanced endothelial function. Thus, our results suggest that GSE appears to be an ergogenic nutraceutical that can improve exercise performance in elite athletes.

Keywords: basketball players; endothelial function; endurance performance; grape seed extract; oxygen consumption.

Publication types

  • Clinical Trial

MeSH terms

  • Antioxidants
  • Basketball*
  • Dietary Supplements
  • Grape Seed Extract* / pharmacology
  • Humans
  • Polyphenols


  • Antioxidants
  • Grape Seed Extract
  • Polyphenols

Grants and funding

This research received no external funding.